Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L-O, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen R C
Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden.
J Intern Med. 2004 Sep;256(3):240-6. doi: 10.1111/j.1365-2796.2004.01380.x.
The First Key Symposium was held in Stockholm, Sweden, 2-5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild Cognitive Impairment (MCI). A multidisciplinary, international group of experts discussed the current status and future directions of MCI, with regard to clinical presentation, cognitive and functional assessment, and the role of neuroimaging, biomarkers and genetics. Agreement on new perspectives, as well as recommendations for management and future research were discussed by the international working group. The specific recommendations for the general MCI criteria include the following: (i) the person is neither normal nor demented; (ii) there is evidence of cognitive deterioration shown by either objectively measured decline over time and/or subjective report of decline by self and/or informant in conjunction with objective cognitive deficits; and (iii) activities of daily living are preserved and complex instrumental functions are either intact or minimally impaired.
首届关键研讨会于2003年9月2日至5日在瑞典斯德哥尔摩举行。该研讨会的目的是整合关于轻度认知障碍（MCI）这一主题的临床和流行病学观点。一个多学科的国际专家小组讨论了MCI在临床表现、认知和功能评估以及神经影像学、生物标志物和遗传学作用方面的现状和未来方向。国际工作组讨论了关于新观点的共识以及管理和未来研究的建议。关于一般MCI标准的具体建议如下：（i）该个体既非正常也未患痴呆；（ii）有认知衰退的证据，表现为随时间客观测量的下降和/或自我和/或 informant 报告的下降与客观认知缺陷相结合；（iii）日常生活活动得以保留，复杂的工具性能力要么完好无损要么仅有轻微受损。
