Associated Retina Consultants Ltd, 7600 N 15th Street, Phoenix, AZ 85020, USA.
J Neurol. 2012 Feb;259(2):386-8. doi: 10.1007/s00415-011-6367-4. Epub 2012 Jan 10.
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and is the common cause of optic neuritis. Fingolimod, an immunosuppressive agent, is used in MS to prevent acute exacerbations. We report a case of relapsing-remitting MS treated with fingolimod. The patient presented with an acute decrease in vision in the left eye. Eye examination showed clinical macular edema (ME) in the left eye, which was confirmed on fluorescein angiogram and optical coherence tomography (OCT). After discontinuation of fingolimod and treatment with topical corticosteroid medication, there was complete resolution of the ME. The ME as a side-effect of fingolimod is reversible after discontinuing, which was seen on OCT.
多发性硬化症（MS）是一种中枢神经系统脱髓鞘疾病，也是视神经炎的常见病因。 fingolimod 是一种免疫抑制剂，用于预防 MS 的急性恶化。我们报告了一例接受 fingolimod 治疗的复发性缓解型 MS 病例。患者左眼视力急性下降。眼部检查显示左眼临床性黄斑水肿（ME），荧光素血管造影和光学相干断层扫描（OCT）证实了这一点。停用 fingolimod 并使用局部皮质类固醇药物治疗后，ME 完全消退。OCT 显示，fingolimod 的 ME 作为一种副作用，停药后是可逆的。
