NIHR Biomedical Research Unit (Nutrition, Diet & Lifestyle) Southampton General Hospital, Southampton, UK.
Acta Paediatr. 2012 May;101(5):524-7. doi: 10.1111/j.1651-2227.2012.02594.x. Epub 2012 Jan 27.
Recent data are scarce on the provision of home parenteral nutrition (HPN) in children from the UK but would help to commission intestinal failure services. Our aim was to describe 10 years of HPN experience in our centre, which serves a population of 650,000 children.
Outcome and complication data were collected retrospectively from hospital records of children receiving HPN from April 2001. Data from other centres were used to compare complications and outcomes in the provision of HPN.
Nineteen children (12 females) received 10,213 days (28 years) of HPN. In this group, incidence of blood culture positive sepsis was four episodes/1000 days PN. Two children had early intestinal failure-associated liver disease. Of the 19, seven still receive HPN at our centre, six survived PN, three were transferred to other services while still on HPN and three died.
Outcome and complication data for HPN from a single UK regional paediatric centre are similar to larger centres. These data provide recent evidence of the disease burden of HPN, which are important for the commissioning of intestinal failure services.
英国儿童家庭肠外营养（HPN）的提供情况鲜有数据报道，但这将有助于肠道衰竭服务的开展。我们的目的是描述我们中心 10 年来的 HPN 经验，该中心服务于 65 万儿童。
从 2001 年 4 月开始，我们从接受 HPN 的儿童的医院记录中回顾性地收集了结果和并发症数据。还使用了其他中心的数据来比较 HPN 提供中的并发症和结果。
19 名儿童（12 名女性）接受了 10213 天（28 年）的 HPN。在这组中，血培养阳性脓毒症的发生率为每 1000 天 PN4 例。有 2 名儿童患有早期肠道衰竭相关肝病。在这 19 名儿童中，有 7 名仍在我们中心接受 HPN，6 名存活，3 名在接受 HPN 的同时转至其他服务，3 名死亡。
来自英国单个儿科区域中心的 HPN 的结果和并发症数据与更大的中心相似。这些数据为 HPN 的疾病负担提供了最新证据，这对于肠道衰竭服务的开展很重要。
