Lund C, Hansen O B, Kehlet H
Department of Anaesthesiology, Hvidovre University Hospital, Denmark.
Br J Anaesth. 1990 Aug;65(2):173-6. doi: 10.1093/bja/65.2.173.
We have studied the effect of surgical injury on cutaneous sensitivity and somatosensory evoked potentials (SSEP) to dermatomal electrical stimulation in 10 patients undergoing hysterectomy. Forty-eight hours after surgery, sensory threshold increased from 2.2 (SEM 0.3) mA to 4.4 (1.1) mA (P less than 0.01) and SSEP amplitudes in P1, N1, P2 and the peak-to-peak amplitudes decreased (P less than 0.05). Latency was prolonged only in the N3 component (P less than 0.05). No changes were seen in threshold and SSEP in a control group studied over the same interval. The results suggest that surgical injury activates antinociceptive modulatory systems.
我们研究了手术创伤对10例行子宫切除术患者皮肤敏感性和皮节电刺激体感诱发电位（SSEP）的影响。术后48小时，感觉阈值从2.2（标准误0.3）毫安增加到4.4（1.1）毫安（P<0.01），P1、N1、P2的SSEP波幅以及峰峰值波幅降低（P<0.05）。仅N3成分的潜伏期延长（P<0.05）。在相同时间段研究的对照组中，阈值和SSEP未见变化。结果表明，手术创伤激活了抗伤害性调制系统。
