Miller C D, Warren S J
Grantham Hospital, Aberdeen, Hong Kong.
Br J Anaesth. 1990 Aug;65(2):216-9. doi: 10.1093/bja/65.2.216.
I.v. lignocaine has been used with varying success to attenuate the cardiovascular responses to laryngoscopy and tracheal intubation. We determined the optimal time of administration in 45 ASA I and II Chinese patients premedicated with morphine and hyoscine, and anaesthetized with thiopentone and suxamethonium. Patients were allocated randomly to a control group or three treatment groups to receive lignocaine 1.5 mg kg-1 i.v. 1, 2, or 3 min before laryngoscopy. Analysis of variance for measured and derived cardiovascular variables failed to show any significant difference between any of the groups.
静脉注射利多卡因用于减轻喉镜检查和气管插管引起的心血管反应，其效果各异。我们在45例接受吗啡和东莨菪碱术前用药、硫喷妥钠和琥珀酰胆碱麻醉的ASA I级和II级中国患者中确定了最佳给药时间。患者被随机分为对照组或三个治疗组，在喉镜检查前1、2或3分钟静脉注射1.5 mg/kg利多卡因。对测量和推导的心血管变量进行方差分析，结果显示各治疗组间无显著差异。
