动力蛋白，一种膜重塑 GTP 酶。
Dynamin, a membrane-remodelling GTPase.
机构信息
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88. doi: 10.1038/nrm3266.
Abstract
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.
摘要
动力蛋白，一种动力蛋白样蛋白家族（DLPs）的创始成员，涉及膜重塑，在胞吞作用的膜裂变事件中起着关键作用。使用互补方法，包括活细胞成像、无细胞研究、X 射线晶体学和在小鼠中的遗传研究，极大地促进了我们对动力蛋白作用机制、其在细胞生理学中的重要作用以及不同动力蛋白同工型的特定功能的理解。此外，动力蛋白与人类疾病之间也存在一些联系，突出了这种 GTP 酶对不同组织生理学的特定贡献。
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