Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA 94305, USA.
Am J Geriatr Psychiatry. 2012 May;20(5):452-6. doi: 10.1097/JGP.0b013e31823e2d03.
Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults.
In a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health.
There was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging.
These findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status appears to be a biomarker of poorer self-rated successful aging, and cognitive performance in older adults.
韧性被认为是成功老龄化的重要组成部分。年轻的成年载有 5-羟色胺转运蛋白基因(5-HTTLPR)短(s)等位基因的个体似乎对压力的韧性降低。我们研究了短等位基因的存在是否与老年人较差的情绪韧性有关。
在一项对 99 名健康的、居住在社区的老年人的横断面研究中,我们确定了 5-HTTLPR 基因型,并进行了 Connor-Davidson 韧性量表和成功老龄化、认知和健康的自我报告测量。
5-HTTLPR s 等位基因与韧性之间没有显著关联。s 等位基因携带者的认知功能和自我报告的成功老龄化评分较差。
这些发现表明,5-HTTLPR s 等位基因对与压力相关的结果的影响可能会随着年龄的增长而减弱。然而,s 等位基因状态似乎是老年人自我报告成功老龄化和认知表现较差的生物标志物。