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1
Emotional experience improves with age: evidence based on over 10 years of experience sampling.情绪体验随着年龄的增长而改善：基于超过 10 年经验抽样的证据。
Psychol Aging. 2011 Mar;26(1):21-33. doi: 10.1037/a0021285.
2
Genetic variation in 5HTTLPR is associated with emotional resilience.5-羟色胺转运体基因连锁多态性区域（5HTTLPR）的基因变异与情绪恢复力有关。
Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):900-6. doi: 10.1002/ajmg.b.30916.
3
Measurement and predictors of resilience among community-dwelling older women.社区居住老年女性复原力的测量与预测因素
J Psychiatr Res. 2008 Dec;43(2):148-54. doi: 10.1016/j.jpsychires.2008.03.007. Epub 2008 May 1.
4
Serotonin transporter polymorphism and stress: a view across the lifespan.血清素转运体多态性与压力：全生命周期视角
Curr Psychiatry Rep. 2007 Jun;9(3):173-5. doi: 10.1007/s11920-007-0014-x.
5
Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol.老年人血清素转运体基因多态性、记忆力与海马体积：与皮质醇的关联及相互作用
Mol Psychiatry. 2007 Jun;12(6):544-55. doi: 10.1038/sj.mp.4001978. Epub 2007 Mar 13.
6
Building blocks of successful aging: a focus group study of older adults' perceived contributors to successful aging.成功老龄化的要素：一项针对老年人对成功老龄化的认知影响因素的焦点小组研究
Am J Geriatr Psychiatry. 2007 Mar;15(3):194-201. doi: 10.1097/JGP.0b013e318030255f.
7
LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity.5-羟色胺转运体基因连锁多态性区域（5HTTLPR）的LA等位基因杂合性与较高的认知功能和较低的人际敏感性相关。
Psychiatr Genet. 2007 Feb;17(1):3-4. doi: 10.1097/YPG.0b013e328010f498.
8
Self-administered cognitive screening for a study of successful aging among community-dwelling seniors: a preliminary study.针对社区居住老年人成功老龄化研究的自我管理认知筛查：一项初步研究。
Int J Geriatr Psychiatry. 2007 Apr;22(4):327-31. doi: 10.1002/gps.1677.
9
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.血清素转运体启动子功能获得性基因型与强迫症有关。
Am J Hum Genet. 2006 May;78(5):815-826. doi: 10.1086/503850. Epub 2006 Mar 28.
10
Correlates of self-rated successful aging among community-dwelling older adults.社区居住老年人自评成功老龄化的相关因素。
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5-HTTLPR 短等位基因、韧性与老年人的成功老龄化。

5-HTTLPR short allele, resilience, and successful aging in older adults.

机构信息

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA 94305, USA.

出版信息

Am J Geriatr Psychiatry. 2012 May;20(5):452-6. doi: 10.1097/JGP.0b013e31823e2d03.

DOI:10.1097/JGP.0b013e31823e2d03
PMID:22233775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3326186/
Abstract

OBJECTIVE

Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults.

METHODS

In a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health.

RESULTS

There was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging.

CONCLUSION

These findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status appears to be a biomarker of poorer self-rated successful aging, and cognitive performance in older adults.

摘要

目的

韧性被认为是成功老龄化的重要组成部分。年轻的成年载有 5-羟色胺转运蛋白基因（5-HTTLPR）短（s）等位基因的个体似乎对压力的韧性降低。我们研究了短等位基因的存在是否与老年人较差的情绪韧性有关。

方法

在一项对 99 名健康的、居住在社区的老年人的横断面研究中，我们确定了 5-HTTLPR 基因型，并进行了 Connor-Davidson 韧性量表和成功老龄化、认知和健康的自我报告测量。

结果

5-HTTLPR s 等位基因与韧性之间没有显著关联。s 等位基因携带者的认知功能和自我报告的成功老龄化评分较差。

结论

这些发现表明，5-HTTLPR s 等位基因对与压力相关的结果的影响可能会随着年龄的增长而减弱。然而，s 等位基因状态似乎是老年人自我报告成功老龄化和认知表现较差的生物标志物。