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Radioimmunoscintigraphy of human pancreatic carcinoma xenografts in nude mice with 131I-labeled monoclonal antibody.

作者信息

Tsuda T, Koshiba H, Usui T, Kubota M, Kikuchi K, Morita K

机构信息

Department of Radiology, Sapporo Medical College, Japan.

出版信息

Ann Nucl Med. 1990 Jul;4(2):71-4. doi: 10.1007/BF03164599.

DOI:10.1007/BF03164599
PMID:2223381
Abstract

Encouraged by reports of radioimmunoimaging of colorectal carcinomas and by examining an immunohistochemical report on resected pancreas cancer tissues, we studied the diagnostic potential of radioimmunoimaging with the radioiodinelabeled monoclonal antibody to the surface antigen of a pancreas cancer cell line. A monoclonal antibody (MoAb; HC-1) to a human pancreas cancer cell line (HGC25)5 was labeled with radioiodine and injected into athymic nude mice implanted with human pancreas cancer cells. Antibody HC-1 was cleared from the circulation and accumulated significantly in the implanted tumor sites.

摘要

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本文引用的文献

1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.由鼠单克隆抗体所界定的人胰腺腺癌细胞抗原
Cancer Res. 1982 Feb;42(2):601-8.
3
Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.用于定位接种于裸鼠的人结肠癌的抗癌胚抗原单克隆抗体的放射性标记片段。
利用人胃癌细胞系对单克隆抗体A7进行体外反应性和体内生物分布研究。
Br J Cancer. 1994 Sep;70(3):405-8. doi: 10.1038/bjc.1994.318.
J Exp Med. 1983 Aug 1;158(2):413-27. doi: 10.1084/jem.158.2.413.
4
Radioactive labeling of antibody: a simple and efficient method.抗体的放射性标记：一种简单高效的方法。
Science. 1983 May 6;220(4597):613-5. doi: 10.1126/science.6836304.
5
Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments.用放射性标记的F(ab')2单克隆抗体片段检测到的转移性结肠癌。
Radiology. 1983 Nov;149(2):549-55. doi: 10.1148/radiology.149.2.6622704.
6
Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts.用于人结肠癌异种移植原位放射免疫检测的放射性标记单克隆抗体（B72.3）的长时间结合。
Cancer Res. 1984 Dec;44(12 Pt 1):5744-51.
7
Radioimmunoscintigraphy of human colon cancer xenografts in mice with radioiodinated monoclonal antibody B72.3.用放射性碘化单克隆抗体B72.3对小鼠体内人结肠癌异种移植物进行放射免疫闪烁显像。
J Nucl Med. 1984 Nov;25(11):1197-203.
8
Specific antigen in serum of patients with colon carcinoma.结肠癌患者血清中的特异性抗原。
Science. 1981 Apr 3;212(4490):53-5. doi: 10.1126/science.6163212.
9
High-specific-activity 111In-labeled anticarcinoembryonic antigen monoclonal antibody: biodistribution and imaging in nude mice bearing human colon cancer xenografts.高比活度111铟标记的抗癌胚抗原单克隆抗体：在荷人结肠癌异种移植瘤裸鼠体内的生物分布及显像
Cancer Res. 1985 Nov;45(11 Pt 2):5700-6.
10
[Immunoscintigraphy and SPECT in patients with pancreatic cancer].胰腺癌患者的免疫闪烁显像与单光子发射计算机断层扫描
Nuklearmedizin. 1985 Dec;24(5-6):232-7.