Dmitrovsky E, Markman M, Marks P A
Cancer Chemother Biol Response Modif. 1990;11:303-20.
Conceptually, the use of cytodifferentiation agents to suppress oncogenicity may prove most effective in long-term continuous treatment of patients whose tumors display some inherent expression of differentiated characteristics. This is the case in many pre-malignant lesions. The difficulty in evaluating the therapeutic role for HMBA, the retinoids, and cytosine arabinoside is oftentimes in separating in vivo cytotoxic from cytodifferentiation effects. Only with further studies will it be determined whether these and other cytodifferentiation agents are therapeutically useful and whether they can provide additional understanding of the processes of cellular transformation and differentiation with which they interact.
从概念上讲，使用细胞分化剂来抑制致癌性，对于那些肿瘤表现出一些分化特征固有表达的患者进行长期持续治疗可能最为有效。许多癌前病变就是这种情况。评估六亚甲基双乙酰胺、维甲酸和阿糖胞苷的治疗作用的困难往往在于区分体内细胞毒性和细胞分化效应。只有通过进一步研究，才能确定这些及其他细胞分化剂是否具有治疗作用，以及它们是否能增进我们对它们所相互作用的细胞转化和分化过程的理解。
