伪狂犬病病毒温度敏感突变体的分离与初步鉴定
Isolation and preliminary characterization of temperature-sensitive mutants of pseudorabies virus.
作者信息
Huy V D, Stäber H, Waschke K, Rosenthal H A
出版信息
Acta Virol. 1977 Sep;21(5):397-404.
PMID:22234
Abstract
Nine ts mutants of pseudorabies virus (PRV) strain BUK were isolated following bromodeoxyuridine (BUdR) or NaNO2 mutagenesis by a selection technique based on a shiftdown from nonpermissive to permissive temperature. This technique is described and its advantages are discussed. The nine ts mutants have been assigned to four complementation groups.
摘要
通过基于从非允许温度向允许温度转变的选择技术，在溴脱氧尿苷（BUdR）或亚硝酸钠诱变后，分离出了伪狂犬病病毒（PRV）BUK株的九个温度敏感（ts）突变体。本文描述了该技术并讨论了其优点。这九个ts突变体已被归入四个互补群。
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