Zhang Ming, Li Zhigao, Zhao Baocheng, Wei Yuzhe, Zhu Guanyu, Ma Yan, Xue Yingwei
Department of Breast Surgery, Harbin Medical University, Harbin, China.
Hepatogastroenterology. 2011 Nov-Dec;58(112):2162-5. doi: 10.5754/hge09129.
BACKGROUND/AIMS: To improve the treatment results for large gastric carcinoma, it is important to know the characteristics of long-term survivors. The aim of this study was to analyze the clinicopathological features of large gastric carcinoma patients and clarify the prognostic factors associated with long-term survival.
Between December 1996 and December 2002, a total of 334 patients entered the study. They underwent surgery for gastric carcinomas measuring 10cm or more in diameter. We examined 12 clinicopathological factors associated with the patient, tumor and surgery. Multivariate analysis was performed using Cox's proportional hazards model.
The 5-year survival rate was influenced by the extent of lymph node dissection, histological type, depth on invasion, lymph node metastasis, peritoneal dissemination, liver metastasis and disease stage. Of these, two independent prognostic factors were depth on invasion and lymph node metastasis.
Depth on invasion and lymph node metastasis emerged as two independent prognostic factors for the prediction of long-term survival in large gastric carcinoma patients. We can make a suitable treatment strategy for patients with gastric cancer through consideration of the prognostic factors.
背景/目的：为提高大型胃癌的治疗效果，了解长期存活者的特征很重要。本研究的目的是分析大型胃癌患者的临床病理特征，并阐明与长期生存相关的预后因素。
1996年12月至2002年12月期间，共有334例患者进入本研究。他们接受了直径10厘米或更大的胃癌手术。我们检查了与患者、肿瘤和手术相关的12个临床病理因素。使用Cox比例风险模型进行多变量分析。
5年生存率受淋巴结清扫范围、组织学类型、浸润深度、淋巴结转移、腹膜播散、肝转移和疾病分期的影响。其中，两个独立的预后因素是浸润深度和淋巴结转移。
浸润深度和淋巴结转移是大型胃癌患者长期生存预测的两个独立预后因素。通过考虑预后因素，我们可以为胃癌患者制定合适的治疗策略。
