Aghakhani K, Kadivar M, Kazemi-Esfeh S, Zamani N, Moradi M, Sanaei-Zadeh H
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Pathol Microbiol. 2011 Oct-Dec;54(4):692-4. doi: 10.4103/0377-4929.91493.
Although one-fourth of the pituitary tumors are inactive and silent, increased total volume of the pituitary gland exerts pressure on sella turcica and corrodes the clinoid processes, resulting in several problems. Therefore, determination of the prevalence of the concealed pituitary tumors is of major concern among clinical practitioners. This study was performed to determine the prevalence of these tumors in cadavers referred to the Iranian Legal Medicine Organization (Kahrizak, Tehran).
This cross-sectional descriptive study was performed between June 2007 and February 2008. A total of 485 cadavers were selected by simple random sampling method. Pituitary glands were removed and then horizontally cut and four slides were prepared from each of them, stained by hematoxylin and eosin, and evaluated by a light microscope. For statistical analysis, SPSS software (version 16), Mann-Whitney U test, Kolmogorov-Smirnov nonparametric test (K-S test), and Chi-square test were used.
Of the 485 investigated cadavers, 365 (75.3%) were males with an average age of 42 ± 20.5 years and 120 (24.7%) were females with an average age of 44 ± 22 years. A total of 61 (12.6%) had concealed pituitary masses. No statistically significant difference was found between the mean age, sex, and body mass index (BMI) of the cadavers with and without concealed tumors (P=0.380 P=0.450, and P=0.884, respectively).
In the present study, the prevalence of the concealed pituitary adenomas was 12.6%. There was no correlation between age, sex, and BMI and the prevalence of the concealed masses.
尽管四分之一的垂体瘤无活性且无症状，但垂体总体积增大对蝶鞍施加压力并侵蚀床突，会引发多种问题。因此，确定隐匿性垂体瘤的患病率是临床医生主要关注的问题。本研究旨在确定转诊至伊朗法医学组织（德黑兰卡赫里扎克）的尸体中这些肿瘤的患病率。
本横断面描述性研究于2007年6月至2008年2月进行。通过简单随机抽样法共选取485具尸体。取出垂体，然后水平切开，每例制作四张玻片，用苏木精和伊红染色，并用光学显微镜进行评估。统计分析采用SPSS软件（16版）、曼-惠特尼U检验、柯尔莫哥洛夫-斯米尔诺夫非参数检验（K-S检验）和卡方检验。
在485例被调查的尸体中，365例（75.3%）为男性，平均年龄42±20.5岁，120例（24.7%）为女性，平均年龄44±22岁。共有61例（12.6%）存在隐匿性垂体肿块。有隐匿性肿瘤和无隐匿性肿瘤的尸体在平均年龄、性别和体重指数（BMI）方面均未发现统计学显著差异（分别为P = 0.380、P = 0.450和P = 0.884）。
在本研究中，隐匿性垂体腺瘤的患病率为12.6%。年龄、性别和BMI与隐匿性肿块的患病率之间无相关性。
