Department of Paediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.
Biomarkers. 2012 Mar;17(2):166-71. doi: 10.3109/1354750X.2011.649494. Epub 2012 Jan 12.
In this study, we investigated the relationship between plasma B-type natriuretic peptide (BNP) levels and hemodynamics from cardiac catheterization in pediatric patients with atrial or ventricular septal defect. A total of 59 patients were studied including 80% of patients had Qp/Qs > 1.5 and 25% of patients had pulmonary hypertension. The mean BNP value and BNP z-score were 10.9 ± 11.2 pg/mL and -0.28 ± 1.7 (-2.85 to 3.29), respectively. There was a statistically significant linear correlation between BNP value and the size of defects (r = 0.303, p = 0.002) and a trend toward to positive correlation between BNP value and Qp/Qs ratio (r = 0.183, p = 0.166) among all patients. To identify patients with a Qp/Qs ratio >1.5, the sensitivity and specificity were 28%, 100% in all patients at a plasma BNP cut-off point of 15 pg/mL. We concluded that a BNP > 15 pg/mL would help identify patients who need further intervention.
在这项研究中，我们研究了经导管心脏造影术中心房或室间隔缺损患儿的血浆 B 型利钠肽（BNP）水平与血液动力学之间的关系。共有 59 名患者参与了研究，其中 80%的患者 Qp/Qs>1.5，25%的患者患有肺动脉高压。BNP 值和 BNP z 评分的平均值分别为 10.9±11.2 pg/mL 和-0.28±1.7(-2.85 至 3.29)。BNP 值与缺损大小之间存在统计学上的显著线性相关（r=0.303，p=0.002），且在所有患者中，BNP 值与 Qp/Qs 比值之间呈正相关趋势（r=0.183，p=0.166）。为了确定 Qp/Qs 比值>1.5 的患者，在所有患者中，当血浆 BNP 截断值为 15 pg/mL 时，其灵敏度和特异性分别为 28%和 100%。我们得出结论，BNP>15 pg/mL 有助于识别需要进一步干预的患者。
