Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
Cancer Invest. 2012 Jan;30(1):13-9. doi: 10.3109/07357907.2011.630052.
rs2352028 in GPC5 has been reported to be associated with the risk of lung cancer in never-smokers. We performed a replication study in 1,045 lung cancer patients and 1,094 controls of Han Chinese origin. We found no association between rs2352028 and lung cancer/adenocarcinoma in never-smokers, but a p value of .04 (under the recessive model) was obtained between this SNP and overall lung cancer/adenocarcinoma. Our data and a recent meta-analysis suspected the possibility of rs2352028 being a risk variant of lung cancer risk in never-smokers. Our findings suggested that rs2352028 might confer a slight risk to lung cancer/adenocarcinoma.
rs2352028 位于 GPC5 中，据报道与不吸烟人群的肺癌风险相关。我们在 1045 例肺癌患者和 1094 例汉族对照中进行了一项复制研究。我们未发现 rs2352028 与不吸烟人群的肺癌/腺癌之间存在关联，但在该 SNP 与总体肺癌/腺癌之间得到了.04 的 P 值（在隐性模型下）。我们的数据和最近的荟萃分析怀疑 rs2352028 可能是不吸烟人群肺癌风险的一个风险变异体。我们的研究结果表明，rs2352028 可能略微增加肺癌/腺癌的发病风险。
