Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021 China.
J Neuroimmunol. 2012 Feb 29;243(1-2):18-24. doi: 10.1016/j.jneuroim.2011.12.003. Epub 2012 Jan 10.
The findings on the associations between potential genetic variants and risk of Guillain-Barré syndrome (GBS) are controversial. We conducted a meta-analysis for candidate genes to provide the evidences for the current understanding of the genetic association with GBS.
We searched relevant studies without language restriction in PubMed, Embase and Cochrane library through May 2011. The strengths of the associations between genetic variants and GBS risk were estimated by odds ratios (ORs) with 95% confidence intervals (CIs). Random-effects models or fixed effects model was applied based on the heterogeneity test.
We identified 12 case-control studies involving 1,590 GBS cases and 2,154 controls for the analysis. Because of limited eligible data, our meta-analysis specifically focused on 6 genetic variants of 3 candidate genes, TNF-α, FcγR and CD1. We found that TNF-α 308 G/A polymorphism was significantly associated with the risk of GBS in the overall population (GG+GA vs. AA: OR=0.32, 95%CI=0.16-0.62; GG vs. AA: OR=0.36, 95%CI=0.19-0.68). Subgroup analysis further provided evidence of significant association between TNF-α 308 G/A and risk of the GBS in Asian population (GG+GA vs. AA: OR=32, 95%CI=0.11-0.93; GG vs. AA: OR=0.32, 95%CI=0.15-0.68). In addition, we did not observe significant associations between FcγRIIA R/H, FcγRIIIA F/V, FcγRIIIB NA1/NA2, CD1A 1/2 and CD1E 1/2 polymorphisms and susceptibility for developing GBS.
Our findings showed that TNF-α 308A allele might be a moderate risk factor for GBS. However, the results should be interpreted with caution due to the limited number of studies available.
关于潜在遗传变异与格林-巴利综合征（GBS）风险之间关联的研究结果存在争议。我们进行了一项候选基因的荟萃分析，为当前对与 GBS 相关的遗传关联的理解提供了证据。
我们在 2011 年 5 月之前，在 PubMed、Embase 和 Cochrane 图书馆中，没有语言限制地搜索了相关研究。使用比值比（OR）及其 95％置信区间（CI）来估计遗传变异与 GBS 风险之间的关联强度。基于异质性检验，应用随机效应模型或固定效应模型。
我们确定了 12 项病例对照研究，共纳入 1590 例 GBS 病例和 2154 名对照者用于分析。由于可用的合格数据有限，我们的荟萃分析特别关注 3 个候选基因 TNF-α、FcγR 和 CD1 的 6 个遗传变异。我们发现 TNF-α 308 G/A 多态性与总体人群的 GBS 风险显著相关（GG+GA 与 AA：OR=0.32，95%CI=0.16-0.62；GG 与 AA：OR=0.36，95%CI=0.19-0.68）。亚组分析进一步提供了 TNF-α 308 G/A 与亚洲人群 GBS 风险之间存在显著关联的证据（GG+GA 与 AA：OR=32，95%CI=0.11-0.93；GG 与 AA：OR=0.32，95%CI=0.15-0.68）。此外，我们未观察到 FcγRIIA R/H、FcγRIIIA F/V、FcγRIIIB NA1/NA2、CD1A 1/2 和 CD1E 1/2 多态性与 GBS 易感性之间存在显著关联。
我们的研究结果表明，TNF-α 308A 等位基因可能是 GBS 的中度危险因素。然而，由于研究数量有限，结果应谨慎解释。
