Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, Germany.
Ann N Y Acad Sci. 2011 Dec;1246:102-7. doi: 10.1111/j.1749-6632.2011.06339.x.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is chronic in nature and is characterized by abdominal pain, diarrhea, bleeding, and malabsorption. It is considered a complex multigenic and multifactorial disorder that results from disturbed interactions between the immune system and commensal bacteria of the gut. Recent work has demonstrated that IBD with an early-onset within the first months of life can be monogenic: mutations in IL-10 or its receptor lead to a loss of IL-10 function and cause severe intractable enterocolitis in infants and small children. Both IL-10 and IL-10 receptor deficiency can be successfully treated by hematopoietic stem cell transplantation.
炎症性肠病（IBD）包括克罗恩病（CD）和溃疡性结肠炎（UC），其具有慢性特征，表现为腹痛、腹泻、出血和吸收不良。它被认为是一种复杂的多基因和多因素疾病，是由免疫系统和肠道共生菌之间的失调相互作用引起的。最近的研究表明，生命早期（出生后最初几个月内）发生的 IBD 可能是单基因疾病：IL-10 或其受体的突变导致 IL-10 功能丧失，并导致婴儿和幼儿出现严重的难治性肠炎。IL-10 和 IL-10 受体缺乏均可通过造血干细胞移植成功治疗。
