Department of Paediatric Gastroenterology, Great Ormond Street Hospital, University College London, London, UK.
Curr Allergy Asthma Rep. 2012 Oct;12(5):373-9. doi: 10.1007/s11882-012-0286-z.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (IL10R) deficiency present with IBD and demonstrate the sensitivity of the intestine to any changes of the immune system. Both IL-10 and IL10R deficiency cause severe early-onset enterocolitis and can be successfully treated by hematopoietic stem cell transplantation (HSCT).
炎症性肠病（IBD）是一种慢性炎症性疾病，其特征为腹痛、血性腹泻和吸收不良导致体重减轻。它被认为是免疫系统对肠道常驻菌群反应过度失控的结果。与其他原发性免疫缺陷一样，IL-10 和 IL-10 受体（IL10R）缺陷也会出现 IBD，并表现出肠道对免疫系统任何变化的敏感性。IL-10 和 IL10R 缺陷都会导致严重的早发性肠炎，可以通过造血干细胞移植（HSCT）成功治疗。
