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本文引用的文献

1
The role of rhinovirus infections in the development of early childhood asthma.鼻病毒感染在婴幼儿哮喘发展中的作用。
Curr Opin Allergy Clin Immunol. 2010 Apr;10(2):133-8. doi: 10.1097/ACI.0b013e3283352f7c.
2
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.美国胸科学会/欧洲呼吸学会官方声明：哮喘控制与加重：规范临床哮喘试验及临床实践的终点指标
Am J Respir Crit Care Med. 2009 Jul 1;180(1):59-99. doi: 10.1164/rccm.200801-060ST.
3
Severe exacerbations and decline in lung function in asthma.哮喘的严重急性加重和肺功能下降
Am J Respir Crit Care Med. 2009 Jan 1;179(1):19-24. doi: 10.1164/rccm.200807-1126OC. Epub 2008 Oct 31.
4
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.幼儿期喘息性鼻病毒疾病可预测高危儿童哮喘的发生。
Am J Respir Crit Care Med. 2008 Oct 1;178(7):667-72. doi: 10.1164/rccm.200802-309OC. Epub 2008 Jun 19.
5
Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers.学龄前喘息儿童气道壁重塑和嗜酸性粒细胞炎症的早期检测
Am J Respir Crit Care Med. 2007 Nov 1;176(9):858-64. doi: 10.1164/rccm.200702-212OC. Epub 2007 Aug 16.
6
Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.生命最初6年哮喘与喘息的转归：随访至青春期
Am J Respir Crit Care Med. 2005 Nov 15;172(10):1253-8. doi: 10.1164/rccm.200504-525OC. Epub 2005 Aug 18.
7
Wheeze phenotypes and lung function in preschool children.学龄前儿童的喘鸣表型与肺功能
Am J Respir Crit Care Med. 2005 Feb 1;171(3):231-7. doi: 10.1164/rccm.200406-695OC. Epub 2004 Oct 22.
8
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood.一项基于人群的儿童哮喘队列纵向研究，随访至成年期。
N Engl J Med. 2003 Oct 9;349(15):1414-22. doi: 10.1056/NEJMoa022363.
9
Spirometric pulmonary function in healthy preschool children.健康学龄前儿童的肺量计肺功能
Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):619-23. doi: 10.1164/ajrccm.163.3.2002054.

在生命早期反复发作严重加重和在校年龄时肺功能降低。

Recurrent severe exacerbations in early life and reduced lung function at school age.

出版信息

J Allergy Clin Immunol. 2012 Apr;129(4):1162-4. doi: 10.1016/j.jaci.2011.11.046. Epub 2012 Jan 10.

DOI:10.1016/j.jaci.2011.11.046
PMID:22236729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3319175/
Abstract

Severe wheezing exacerbations during the preschool years, a critical time in lung growth and development, may lead to airway damage and remodeling. Our study linked these events to a partially reversible reduction in lung function present at school age.

摘要

在肺部生长和发育的关键时期——学前期，严重的喘息加重可能导致气道损伤和重塑。我们的研究将这些事件与学龄期出现的部分可逆转的肺功能下降联系起来。