Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France.
Int J Tuberc Lung Dis. 2012 Feb;16(2):221-3, i-ii. doi: 10.5588/ijtld.11.0266.
In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.
在柬埔寨进行的一项研究中，氟喹诺酮类耐药（FQ-R）耐多药（MDR）菌株中与吡嗪酰胺耐药（PZA-R）相关的 pncA 基因突变的结核分枝杆菌（TB）菌株数量较高（93%），而 MDR 和非 MDR 菌株中分别为 47%和 3%。这强调了需要简便快速的 PZA-R 检测方法，以有效治疗 MDR-TB。
