Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK.
Cell Death Dis. 2012 Jan 12;3(1):e247. doi: 10.1038/cddis.2011.122.
The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.
早幼粒细胞白血病基因 PML 最初是在急性早幼粒细胞白血病的 t(15;17)易位中被鉴定出来的，该易位产生了癌基因 PML-视黄酸受体 α。PML 是一种亚核结构的代表，称为 PML 核体。目前的模型提出，PML 通过其支架特性能够在许多不同的水平上控制细胞的生长和存活。在这里，我们讨论了当前的文献，并提出了新的研究途径。
