Al-Beladi Fatma I
Department of Medicine, King Abdul Aziz University Hospital, Jeddah, Saudi Arabia.
Saudi J Kidney Dis Transpl. 2012 Jan;23(1):110-3.
Antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies with characteristic clinical manifestation, which include venous, arterial thrombosis, thrombotic microangiopathy, and recurrent fetal loss. The syndrome can be secondary to many causes including systemic lupus erythematosus (SLE) or "primary" antiphospholipid syndrome (APLS). We report a case of a man with catastrophic antiphospholipid syndrome (CAPS), which occurs when three or more organ systems are affected by thrombosis in less than a week. Catastrophic antiphospholipid syndrome is uncommon but often fatal. The patient received a successful treatment that controlled this disease and included intravenous heparin, antiplatelet, intravenous corticosteroid, and plasmapheresis.
抗磷脂综合征的特征是存在抗磷脂抗体并伴有特征性临床表现，包括静脉血栓、动脉血栓形成、血栓性微血管病和复发性流产。该综合征可继发于多种病因，包括系统性红斑狼疮（SLE）或“原发性”抗磷脂综合征（APLS）。我们报告一例患有灾难性抗磷脂综合征（CAPS）的男性病例，该综合征指在不到一周的时间内三个或更多器官系统受到血栓形成影响。灾难性抗磷脂综合征并不常见，但往往致命。该患者接受了成功控制该病的治疗，包括静脉注射肝素、抗血小板药物、静脉注射皮质类固醇和血浆置换。
