Department of Chemistry and Biology, Ryerson University, Toronto, Canada.
Food Funct. 2012 Mar;3(3):302-11. doi: 10.1039/c2fo10203j. Epub 2012 Jan 12.
Oil-in-water (O/W) emulsions solely stabilized by surface-active solid lipid nanoparticles (SLNs) were developed. The SLNs were generated by quench-cooling hot O/W nanoemulsions consisting of 7.5% glyceryl stearyl citrate (GSC) dispersed in water. Their initial volume-weighted mean particle diameter (∼152 nm) and zeta potential (ca.-49 mV) remained unchanged for 24 weeks. O/W emulsions (oil phase volume fraction: 0.2) containing 7.5% (w/w) GSC SLNs in the aqueous phase were kinetically-stable for 12 weeks and did not visually phase-separate over 24 weeks. The O/W emulsions generated with solid-state GSC SLNs had a volume-weighted mean oil droplet diameter of ∼459 nm and a zeta potential of ca.-43 mV. Emulsion microstructure evaluated with TEM revealed dispersed oil droplets sparsely covered with adsorbed Pickering-type SLNs as well aggregated SLNs present in the continuous phase. Gradual emulsion destabilization resulted from GSC SLN dissolution during the experimental timeframe. Overall, surface-active SLNs developed via nanoemulsions effectively kinetically stabilized O/W emulsions.
制备了仅由表面活性固体脂质纳米粒（SLN）稳定的油包水（O/W）乳液。SLN 是通过淬冷由 7.5%甘油硬脂酸酯柠檬酸酯（GSC）分散在水中形成的热 O/W 纳米乳液而产生的。其初始体积加权平均粒径（约 152nm）和 Zeta 电位（约-49mV）在 24 周内保持不变。在水相中含有 7.5%（w/w）GSC SLN 的 O/W 乳液（油相体积分数：0.2）在 12 周内具有动力学稳定性，在 24 周内不会发生肉眼可见的相分离。用固态 GSC SLN 制备的 O/W 乳液的体积加权平均油滴直径约为 459nm，Zeta 电位约为-43mV。用 TEM 评估的乳液微观结构显示，分散的油滴稀疏地覆盖着吸附的 Pickering 型 SLN 以及存在于连续相中的聚集 SLN。在实验期间，由于 GSC SLN 的溶解，乳液逐渐失稳。总体而言，通过纳米乳液开发的表面活性 SLN 有效地对 O/W 乳液进行了动力学稳定。
