Nephrology Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Int J Vitam Nutr Res. 2011 Jul;81(4):197-203. doi: 10.1024/0300-9831/a000065.
Some studies have hypothesized the protective role of vitamin C against cardiovascular disorders (CVD) in patients with end-stage renal disease (ESRD). This study was designed to assess plasma vitamin C concentration and its relationship to hemodialysis (HD) patients' morbidity and mortality.
Plasma vitamin C concentrations were assessed in HD patients using spectrophotometry and subjects were prospectively followed for up eighteen months for all-cause mortality. Any association between vitamin C concentration and patients' demographic data, co-morbidities, or the cause of ESRD were investigated using the Chi-square test.
Ninety-one patients with a mean age of 56.7 ± 15.7 years were included in this study. The most frequent cause of ESRD was simultaneous hypertension and diabetes in 30 % of patients, followed by hypertension in 25.6 %, and diabetes in 11.1 %, respectively. About 34 % of patients had CVD as the most prevalent co-morbidity. Forty-nine patients (53.8 %) had low levels of vitamin C concentration. There was a significant relationship between vitamin C insufficiency and presence of any co-morbidity in HD patients (p < 0.05). There was a significant difference in vitamin C concentrations between patients without co-morbidities and those with cardiovascular ones (F[2,88]=3.447, p = 0.036). Twenty-two (24.2 %) patients died over a median duration of 227 days. There was a significant difference in time to death of patients with and without low levels of vitamin C concentration (p = 0.04).
The results showed lower plasma vitamin C levels in HD patients who suffered any co-morbidity and sooner time to death in these patients.
一些研究假设维生素 C 对终末期肾病 (ESRD) 患者的心血管疾病 (CVD) 具有保护作用。本研究旨在评估血液透析 (HD) 患者的血浆维生素 C 浓度及其与发病率和死亡率的关系。
使用分光光度法评估 HD 患者的血浆维生素 C 浓度，并前瞻性随访 18 个月，以评估所有原因的死亡率。使用卡方检验研究维生素 C 浓度与患者的人口统计学数据、合并症或 ESRD 病因之间的任何关联。
本研究纳入了 91 名平均年龄为 56.7 ± 15.7 岁的患者。ESRD 的最常见病因是同时患有高血压和糖尿病，占 30%，其次是高血压占 25.6%，糖尿病占 11.1%。约 34%的患者患有 CVD 作为最常见的合并症。49 名患者（53.8%）维生素 C 浓度水平较低。维生素 C 不足与 HD 患者存在任何合并症之间存在显著关系（p < 0.05）。无合并症患者与有心血管合并症患者之间的维生素 C 浓度存在显著差异（F[2,88]=3.447，p = 0.036）。中位随访时间为 227 天期间，有 22 名（24.2%）患者死亡。维生素 C 水平低的患者与维生素 C 水平正常的患者之间的死亡时间存在显著差异（p = 0.04）。
研究结果表明，患有任何合并症的 HD 患者的血浆维生素 C 水平较低，且这些患者的死亡时间更早。
