Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK.
Int J Vitam Nutr Res. 2011 Jul;81(4):240-4. doi: 10.1024/0300-9831/a000069.
Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with hypertension. The B-vitamin riboflavin is required as a cofactor by MTHFR and recent evidence suggests it may have a role in modulating blood pressure, specifically in those with the homozygous mutant MTHFR 677 TT genotype. If studies confirm that this genetic predisposition to hypertension is correctable by low-dose riboflavin, the findings could have important implications for the management of hypertension given that the frequency of this polymorphism ranges from 3 to 32 % worldwide.
高血压是心血管疾病（CVD）和中风的主要危险因素。先前已确定编码酶亚甲基四氢叶酸还原酶（MTHFR）的基因中的一种常见多态性是同型半胱氨酸浓度升高的主要遗传决定因素，并且也被认为是 CVD 的一个危险因素，它似乎与高血压独立相关。维生素 B 族的核黄素是 MTHFR 的必需辅助因子，最近的证据表明它可能在调节血压方面发挥作用，特别是在那些纯合子突变 MTHFR 677 TT 基因型的人。如果研究证实这种高血压的遗传易感性可以通过低剂量核黄素纠正，那么这些发现对于高血压的管理可能具有重要意义，因为这种多态性的频率在全球范围内从 3%到 32%不等。
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