Universite Bordeaux Segalen, Institut de Sante Publique d'Epidemiologie et de Developpement, Laboratoire Sante Travail Environnement, Centre INSERM U, Equipe Associee en Sante Travail, Bordeaux, France.
Am J Ind Med. 2012 May;55(5):440-9. doi: 10.1002/ajim.22008. Epub 2012 Jan 11.
In the course of setting up the National Mesothelioma Surveillance Program (PNSM), established in France in 1998, the question arose as to the most suitable method of assessing occupational exposure. The aim of this study was to define the most suitable rating method for assessing occupational asbestos exposure in order to assess medico-social care.
The study included 100 subjects-50 cases of mesothelioma and 50 controls-randomly selected and representing 457 jobs held. Job asbestos exposure was assessed by a six-expert panel using two methods: "by job" rating, where all the jobs in were assessed regardless of the subjects; and "by subject" rating, where all the jobs of a subject were assessed at the same time. Consensus was obtained and subjects' exposure was calculated for each rating. Then, two internal experts assessed job asbestos exposure with the "by subject" rating. Kappa coefficients were used to measure agreement between the ratings.
Agreement between "by job" and "by subject" ratings was very good for subject probability of exposure (kappa = 0.84) and cumulative exposure index (kappa = 0.80). Agreement between the six-expert panel and the two internal experts was good for subject exposure (kappa for probability = 0.71; kappa for cumulative exposure index= 0.68).
This study shows that the two rating systems have good or very good agreement. These results validate the routine use in the PNSM of the "by subject" rating, with the advantage of being convenient and quick to provide feedback on occupational asbestos exposure to mesothelioma cases for compensation.
1998 年在法国设立国家间皮瘤监测计划(PNSM)的过程中,出现了评估职业暴露的最佳方法的问题。本研究的目的是确定评估职业石棉暴露的最合适评分方法,以便评估医疗社会护理。
该研究纳入了 100 名受试者-50 例间皮瘤病例和 50 名对照,随机选择并代表 457 项工作。职业石棉暴露由六名专家小组使用两种方法进行评估:“按工作”评分,无论受试者如何,都对所有工作进行评估;和“按主体”评分,同时评估一个主体的所有工作。得出了共识,并为每个评分计算了受试者的暴露量。然后,两名内部专家使用“按主体”评分评估了工作的石棉暴露情况。使用 Kappa 系数来衡量评分之间的一致性。
“按工作”和“按主体”评分之间的一致性非常好,包括主体暴露的可能性(kappa=0.84)和累积暴露指数(kappa=0.80)。六位专家小组与两位内部专家之间的一致性很好,主体暴露(可能性的 kappa 值=0.71;累积暴露指数的 kappa 值=0.68)。
本研究表明,两种评分系统具有良好或非常好的一致性。这些结果验证了 PNSM 中“按主体”评分的常规使用,其优点是方便快捷,可迅速为间皮瘤病例的职业石棉暴露提供补偿方面的反馈。