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唑系列中直接 C-H 芳基化反应的最新进展：方法学、选择性和机制。

Recent advances in direct C-H arylation: Methodology, selectivity and mechanism in oxazole series.

机构信息

UMR COBRA 6014 - Université et INSA de Rouen, IRCOF, Laboratoire de Chimie Organique Fine et Hétérocyclique, BP08, 76131 Mont Saint Aignan, France.

出版信息

Beilstein J Org Chem. 2011;7:1584-601. doi: 10.3762/bjoc.7.187. Epub 2011 Nov 29.

DOI:10.3762/bjoc.7.187
PMID:22238536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3252862/
Abstract

Catalytic direct (hetero)arylation of (hetero)arenes is an attractive alternative to traditional Kumada, Stille, Negishi and Suzuki-Miyaura cross-coupling reactions, notably as it avoids the prior preparation and isolation of (hetero)arylmetals. Developments of this methodology in the oxazole series are reviewed in this article. Methodologies, selectivity, mechanism and future aspects are presented.

摘要

催化直接（杂）芳基化（杂）芳烃是一种有吸引力的替代传统的 Kumada、Stille、Negishi 和 Suzuki-Miyaura 交叉偶联反应的方法，特别是因为它避免了（杂）芳基金属的预先制备和分离。本文综述了噁唑系列中该方法的发展。介绍了方法学、选择性、机理和未来方面。

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