多年冻土微生物对免疫系统形态功能活性影响的实验研究

Experimental study of the effects of permafrost microorganisms on the morphofunctional activity of the immune system.

作者信息

Kalenova L F, Suhovey U G, Broushkov A V, Melnikov V P, Fisher T A, Besedin I M, Novikova M A, Efimova J A, Subbotin A M

机构信息

Tyumen Research Center, Siberian Division of Russian Academy of Sciences, Russia.

出版信息

Bull Exp Biol Med. 2011 Jun;151(2):201-4. doi: 10.1007/s10517-011-1289-9.

DOI:10.1007/s10517-011-1289-9

PMID:22238750

Abstract

The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 10(6) microbial bodies caused characteristic dose-dependent effects on the structure and functions of the immune system (thymus and spleen indexes, functional activity of splenic macrophages, cellular and humoral immunity). Doses of PMO stimulating functional activities of both cellular and humoral immunity were detected.

摘要

对从雅库特猛犸象山采集的多年冻土样本（PMO菌株3M）中分离出的一种新型微生物的免疫生物学潜力，在实验室小鼠中进行了研究。以2500至50×10(6)个微生物体的剂量腹腔注射PMO，对免疫系统的结构和功能（胸腺和脾脏指数、脾巨噬细胞的功能活性、细胞免疫和体液免疫）产生了典型的剂量依赖性影响。检测到了能刺激细胞免疫和体液免疫功能活性的PMO剂量。