Laudignon N, Aranda J V, Varma D R
Department of Pharmacology and Therapeutics, Montreal Children's Hospital, McGill University, Canada.
Biol Neonate. 1990;58(2):91-7. doi: 10.1159/000243238.
Vasorelaxant effects of adenosine and its analogues, 5'-N-(ethylcarboxamide) adenosine (NECA), N6-(l-phenylisopropyl)-adenosine (l-PIA) and N6-cyclohexyladenosine (CHA), on isolated internal carotid arteries from newborn (1-3 days) and adult (6 months) pigs were compared. The order of vasorelaxant potencies of adenosines was: NECA greater than l-PIA greater than adenosine greater than CHA for the adult arteries and NECA greater than l-PIA greater than adenosine = CHA for the newborn arteries. Sensitivities of vessels from the newborn and mature animals to CHA and l-PIA did not differ. However, carotid arteries from the newborn pigs were less sensitive to NECA and adenosine than the adult arteries (p less than 0.05). Theophylline caused an approximately 3-fold shift to the right of the relaxant concentration-response curves to all the four adenosines on arteries from pigs of both age groups. These data suggest that adenosine is not as effective a vasodilator in the newborn as it is in the adult.
比较了腺苷及其类似物5'-N-（乙基甲酰胺）腺苷（NECA）、N6-（1-苯异丙基）腺苷（l-PIA）和N6-环己基腺苷（CHA）对新生（1-3天）和成年（6个月）猪离体颈内动脉的血管舒张作用。对于成年动脉，腺苷类药物的血管舒张效力顺序为：NECA＞l-PIA＞腺苷＞CHA；对于新生动脉，顺序为：NECA＞l-PIA＞腺苷 = CHA。新生动物和成年动物的血管对CHA和l-PIA的敏感性无差异。然而，新生猪的颈内动脉对NECA和腺苷的敏感性低于成年动脉（p＜0.05）。茶碱使两个年龄组猪动脉上所有四种腺苷的舒张浓度-反应曲线向右移动约3倍。这些数据表明，腺苷在新生动物中作为血管舒张剂的效果不如在成年动物中。
