Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy.
Ann N Y Acad Sci. 2011 Jul;1229:E1-7. doi: 10.1111/j.1749-6632.2011.06205.x.
The scavenger receptor class B type I (SR-B1) plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR-B1 is a high-density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR-B1 does this is unclear. Other than its role as an HDL receptor, SR-B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR-B1 has been thus far associated.
清道夫受体 B 类 I 型（SR-B1）在介导肝脏和类固醇生成组织中 HDL 来源的胆固醇和胆固醇酯的摄取方面发挥重要作用。除了普遍存在外，SR-B1 还是许多组织中的高密度脂蛋白（HDL）受体，尽管其作用机制尚不清楚。除了作为 HDL 受体的作用外，SR-B1 还参与病原体识别；其表达可以被脂多糖和氧化应激调节；并且在脂溶性维生素（如维生素 E 和类胡萝卜素）的摄取中起重要作用。在这篇简短的综述中，我们总结了迄今为止与 SR-B1 相关的生物学方面。
