改善杜氏肌营养不良症身体机能的营养策略。
Nutrition strategies to improve physical capabilities in Duchenne muscular dystrophy.
作者信息
Davoodi J, Markert C D, Voelker K A, Hutson S M, Grange Robert W
机构信息
Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24061, USA.
出版信息
Phys Med Rehabil Clin N Am. 2012 Feb;23(1):187-99, xii-xiii. doi: 10.1016/j.pmr.2011.11.010. Epub 2011 Dec 13.
Abstract
There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticosteroids. This article describes 2 potential nutritional interventions for the treatment of DMD, green tea extract (GTE) and the branched-chain amino acid leucine, and their positive effects on physical activity. Both GTE and leucine are suitable for human consumption, are easily tolerated with no side effects, and, with appropriate preclinical data, could be brought forward to clinical trials rapidly.
摘要
目前尚无治疗杜氏肌营养不良症（DMD）的方法，除皮质类固醇外，改善患者生活质量的姑息性和预防性干预措施仍然有限。本文介绍了两种治疗DMD的潜在营养干预措施，即绿茶提取物（GTE）和支链氨基酸亮氨酸，以及它们对身体活动的积极影响。GTE和亮氨酸都适合人类食用，易于耐受且无副作用，并且有适当的临床前数据，可以迅速推进到临床试验。
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