1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary.
Clin Hemorheol Microcirc. 2012;50(3):179-87. doi: 10.3233/CH-2011-1424.
Several beneficial effects of resveratrol (RES), a natural antioxidant present in red wine have already been described. The aim of our study was to investigate if RES had a clinically measurable cardioprotective effect in patients after myocardial infarction. In this double-blind, placebo controlled trial 40 post-infarction Caucasian patients were randomized into two groups. One group received 10 mg RES capsule daily for 3 months. Systolic and diastolic left ventricular function, flow-mediated vasodilation (FMD), several laboratory and hemorheological parameters were measured before and after the treatment. Left ventricular ejection fraction showed an increasing tendency (ns) by RES treatment. However, left ventricular diastolic function was improved significantly (p < 0.01) by RES. A significant improvement in endothelial function measured by FMD was also observed (p < 0.05). Low-density lipoprotein (LDL) level significantly decreased (p < 0.05) in the RES treated group. Red blood cell deformability decreased and platelet aggregation increased significantly in the placebo group (p < 0.05), while resveratrol treatment has prevented these unfavourable changes. Concerning other measured parameters no significant changes were observed neither in placebo nor in RES group. Our results show that resveratrol improved left ventricle diastolic function, endothelial function, lowered LDL-cholesterol level and protected against unfavourable hemorheological changes measured in patients with coronary artery disease (CAD).
白藜芦醇（RES）是一种存在于红酒中的天然抗氧化剂，其具有多种有益作用。本研究旨在探究 RES 是否对心肌梗死后患者具有临床可测量的心脏保护作用。在这项双盲、安慰剂对照试验中，将 40 名白人心梗后患者随机分为两组。一组患者每天服用 10mg RES 胶囊，持续 3 个月。在治疗前后测量了左心室收缩和舒张功能、血流介导的血管扩张（FMD）、多项实验室和血液流变学参数。RES 治疗后左心室射血分数呈上升趋势（无统计学差异）。然而，RES 可显著改善左心室舒张功能（p<0.01）。FMD 测量的内皮功能也有显著改善（p<0.05）。RES 治疗组的低密度脂蛋白（LDL）水平显著降低（p<0.05）。与 RES 组相比，安慰剂组的红细胞变形能力显著降低，血小板聚集显著增加（p<0.05），而 RES 治疗可预防这些不利变化。在安慰剂组和 RES 组中，均未观察到其他测量参数有显著变化。我们的结果表明，RES 可改善左心室舒张功能、内皮功能、降低 LDL-胆固醇水平，并预防冠心病患者的血液流变学不利变化。
