Steinstraesser L, Kueckelhaus M, Koljonen V
BG Kliniken Bergmannsheil, Ruhr Universität Bochum, Klinik für Plastische Chirurgie und Schwerbrandverletzte, Bochum.
Handchir Mikrochir Plast Chir. 2011 Dec;43(6):345-9. doi: 10.1055/s-0030-1269932. Epub 2012 Jan 12.
Merkel cell carcinoma (MCC) is a carcinoma arising from Merkel cells located in the basal layer of the epidermis. The skin of the head and neck is a common site for MCC, occurring generally in fair-skinned elderly patients. MCC is considered as the most lethal skin cancer. Radical surgical excision with pathological verification of complete removal of the tumour is the recommended treatment. Early MCC can be cured by surgery with or without postoperative radiation therapy, whereas advanced MCC is currently considered to be incurable. In the year 2008, a new polyoma virus was found in the tumour genome of the MCC tumours. MCPyV (Merkel cell polyoma virus) appears to be the first example of a human oncogenic polyoma virus. Specific mutations in the viral genome and its clonal integration to the tumour genome are strong evidence against MCPyV as being a passenger virus that secondarily infects MCC tumours. The purpose of this review article is to shed light on this rare skin cancer and introduce the latest advances in research on MCC.
默克尔细胞癌（MCC）是一种起源于位于表皮基底层的默克尔细胞的癌症。头颈部皮肤是MCC的常见发病部位，通常发生在皮肤白皙的老年患者身上。MCC被认为是最致命的皮肤癌。推荐的治疗方法是进行根治性手术切除，并通过病理检查证实肿瘤已完全切除。早期MCC通过手术联合或不联合术后放疗可以治愈，而晚期MCC目前被认为无法治愈。2008年，在MCC肿瘤的基因组中发现了一种新的多瘤病毒。默克尔细胞多瘤病毒（MCPyV）似乎是人类致癌多瘤病毒的首个实例。病毒基因组中的特定突变及其与肿瘤基因组的克隆整合有力地证明MCPyV并非继发感染MCC肿瘤的过客病毒。这篇综述文章的目的是阐明这种罕见的皮肤癌，并介绍MCC研究的最新进展。
