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朝向更真实的乳房恶性肿瘤生物力学建模。

Towards a more realistic biomechanical modelling of breast malignant tumours.

机构信息

Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK.

出版信息

Phys Med Biol. 2012 Feb 7;57(3):631-48. doi: 10.1088/0031-9155/57/3/631. Epub 2012 Jan 12.

Abstract

We develop a biomechanical model of an isolated stellate breast tumour under mammographic compression forces for a range of reported mechanical properties, both linear elastic and hyperelastic. We also introduce different volumes of increased density/stiffness around the tumour as well as a solid pressure effect. We show that each of these issues--well known to clinicians but ignored to date in models--has a non-negligible effect on stresses and strains/deformations.

摘要

我们为一系列报道的机械性能(包括线弹性和超弹性)开发了一个在乳腺摄影压缩力下孤立星状乳腺肿瘤的生物力学模型。我们还引入了肿瘤周围不同密度/刚度的增加体积以及固体压力效应。我们表明,这些问题中的每一个——临床医生众所周知但迄今为止在模型中被忽略——对应力和应变/变形都有不可忽视的影响。

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