Fried G M, Ayeni O R, Brown R A, Lough J
Can J Surg. 1979 Jul;22(4):354-5.
Verner and Morrison, in 1958, reported non-insulin-secreting tumours of the pancreas that were associated with a syndrome of refractory diarrhea, achlorhydria and hypokalemia. Surgical resection of such tumours results in rebound acid hypersecretion and cessation of the watery diarrhea. The authors report the case of an 84-year-old man who had three of the four major criteria for diagnosis of the Verner Morrison syndrome. Hypokalemia was absent, but this was possibly due to the large doses of potassium chloride that he was taking in conjunction with diuretics. After resection of the tumour severe obstipation with resultant bowel obstruction developed in addition to rebound hypersecretion and relief of watery diarrhea. Treatment, consisting of bulk laxatives in appropriate amounts, alleviated the obstipation.
1958年，弗纳和莫里森报告了胰腺的非胰岛素分泌肿瘤，这些肿瘤与难治性腹泻、胃酸缺乏和低钾血症综合征有关。手术切除此类肿瘤会导致胃酸分泌反弹性增加和水样腹泻停止。作者报告了一名84岁男性的病例，该患者具备弗纳 - 莫里森综合征诊断的四项主要标准中的三项。虽无低钾血症，但这可能是因为他同时服用大剂量氯化钾和利尿剂。肿瘤切除后，除了胃酸分泌反弹和水样腹泻缓解外，还出现了严重便秘并导致肠梗阻。使用适量容积性泻药的治疗缓解了便秘。
