Cohle S D, Tschen J A, Smith F E, Lane M, McGavran M H
Cancer. 1979 Jun;43(6):2370-6. doi: 10.1002/1097-0142(197906)43:6<2370::aid-cncr2820430630>3.0.co;2-x.
We report a case of ACTH-secreting carcinoma of the breast. Membrane-bound secretory granules were seen within the cancer cells electron microscopically. Cytoplasmic granules reacting immunochemically to anti-ACTH antisera were seen on light microscopy. Breast cancers have been shown to secrete calcitonin, parathyroid hormone, human chorionic gonadotropin, and norepinephrine in addition to ACTH. This suggests either the presence of neuroendocrine cells in the breast as a source of such neoplasms, as in the lung, or genomic derepression during neoplastic transformation.
我们报告一例分泌促肾上腺皮质激素（ACTH）的乳腺癌病例。在电子显微镜下可见癌细胞内有膜结合分泌颗粒。在光学显微镜下可见对抗ACTH抗血清有免疫化学反应的细胞质颗粒。除ACTH外，乳腺癌还被证明可分泌降钙素、甲状旁腺激素、人绒毛膜促性腺激素和去甲肾上腺素。这表明乳腺中存在神经内分泌细胞作为此类肿瘤的来源，就像在肺中一样，或者是肿瘤转化过程中的基因组去抑制。
