Klin Med (Mosk). 2011;89(5):60-4.
The authors summarize recent data on the predisposition to, indications for, and efficacy of immunomodulating therapy of immunocompromised patients presenting with allergia. Clinical and immunological characteristic of pathology is presented including cytokine status before and after therapy. High efficacy of immunomodulators like interferons is exemplified by the most efficacious of them, cycloferon (meglumin acridonacetate). Disturbed immune reactivity promotes the development of pathological process. Results of the studies of various aspects of immunogenesis suggest desirability of inclusion of cycloferon therapy in the combined treatment of the disease under consideration. New aspects of clinical use of the immunomodulator cycloferon in combination with allergen-specific immunotherapy are discussed.
作者总结了免疫功能低下且伴有过敏症患者免疫调节治疗的易感性、适应症及疗效的近期数据。介绍了该病症的临床和免疫学特征，包括治疗前后的细胞因子状态。以最有效的免疫调节剂如干扰素为例，其中环磷酰胺（甲磺酸阿糖腺苷）具有高效性。免疫反应紊乱促进了病理过程的发展。免疫发生各个方面的研究结果表明，在考虑的疾病联合治疗中纳入环磷酰胺治疗是可取的。讨论了免疫调节剂环磷酰胺与变应原特异性免疫治疗联合临床应用的新方面。
