组蛋白去乙酰化酶 HDAC5 的调控核穿梭可能会抑制可卡因成瘾。
Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
机构信息
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Neuron. 2012 Jan 12;73(1):1-3. doi: 10.1016/j.neuron.2011.12.016.
PMID:22243740
Abstract
The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.
摘要
组蛋白去乙酰化酶 HDAC5 已被证明可以调节可卡因的行为适应。在本期《神经元》杂志上，Taniguchi 等人（2012）描述了一种 cAMP 依赖性信号通路，该通路调节 HDAC5 的核积累，这表明了一种将可卡因与 HDAC5 功能变化偶联的机制。
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