Freie Universität Berlin, NeuroCure Cluster of Excellence & Charité Berlin, 14195 Berlin, Germany.
Neuron. 2012 Jan 12;73(1):3-5. doi: 10.1016/j.neuron.2011.12.015.
In addition to activity-dependent neurotransmission, neurons can undergo spontaneous activity-independent neurotransmitter release with low probability. In this issue of Neuron, Ramirez et al. (2012) now identify the noncanonical endosomal SNARE Vps10p-tail-interactor1a (Vti1a) as a regulator of spontaneously fusing vesicles.
除了依赖于活动的神经递质传递,神经元也可以以低概率进行不依赖于活动的自发性神经递质释放。在本期的《神经元》杂志上,Ramirez 等人(2012)现在确定了非常规内体 SNARE Vps10p-尾相互作用蛋白 1a(Vti1a)是调节自发性融合囊泡的一个调控因子。