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棕榈酸乙醇酰胺可刺激小胶质细胞吞噬大肠杆菌 K1 和肺炎链球菌 R6。

Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells.

机构信息

Department of Neuropathology, Georg-August-University, Göttingen, Germany.

出版信息

J Neuroimmunol. 2012 Mar;244(1-2):32-4. doi: 10.1016/j.jneuroim.2011.12.013. Epub 2012 Jan 12.

DOI:10.1016/j.jneuroim.2011.12.013
PMID:22244572
Abstract

The ability of microglial cells to phagocytose bacteria after stimulation with the endocannabinoid palmitoylethanolamide (PEA) was studied in vitro. PEA increased the phagocytosis of unencapsulated Streptococcus pneumoniae R6 and encapsulated Escherichia coli K1 by murine microglial cells significantly after 30 min of microglial stimulation. This suggested that stimulation of microglial cells by PEA can increase the resistance of the brain against CNS infections.

摘要

研究了在受到内源性大麻素棕榈酰乙醇酰胺（PEA）刺激后，小胶质细胞吞噬细菌的能力。体外实验表明，在小胶质细胞刺激 30 分钟后，PEA 可显著增加未包裹的肺炎链球菌 R6 和包裹的大肠杆菌 K1 被鼠小胶质细胞吞噬的能力。这表明 PEA 刺激小胶质细胞可以提高大脑对中枢神经系统感染的抵抗力。

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