Kido H, Tomihara Y, Watanabe I, Ohsawa N, Katunuma N
Cancer Res. 1979 Aug;39(8):3258-61.
One component of a factor in Proteus mirabilis (Factor 1) which specifically amplifies the induction of several liver enzymes by glucocorticoid in target cells also increases the growth inhibition of glucocorticoid on the ascitic form of L1210 cells and solid tumors of L5178Y lymphoblasts in vivo. The growth of L5U78Y and L1210 lymphoblasts was inhibited by a triamcinolone acetonide dose of over 0.5 to 1.0 mg/kg body weight. Factor 1 increased the inhibitory effect of a triamcinolone acetonide dose of less than 4.0 mg/kg bodyweight but had little effect on the effects of doses of over 4.0 mg. Factor 1 (10 biological units/kg body weight) itself also caused marked inhibition of the growth of these lymphoblasts without affecting the body weight or adrenal gland weight, its effect being equivalent to that of 3- to 4-mg/kg body weight doses of triamcinolone acetonide alone. There was no significant difference in the level of plasma total corticoids or that of plasma adrenocorticotropic hormone between rats treated with 0.9% NaCl solution or those treated with Factor 1, and Factor 1 had no cytotoxic effec on cultured L5178Y lymphoblasts. Thus, Factor 1 may amplify the effect of physiological level of glucocorticoid in mice sufficiently to inhibit the growth of these lymphoblasts without causing any significant side effects to the host animal.
奇异变形杆菌中的一种因子成分（因子1），它能特异性增强糖皮质激素对靶细胞中几种肝酶的诱导作用，在体内还能增强糖皮质激素对L1210腹水癌细胞和L5178Y淋巴母细胞实体瘤生长的抑制作用。当曲安奈德剂量超过0.5至1.0毫克/千克体重时，L5U78Y和L1210淋巴母细胞的生长受到抑制。因子1增强了曲安奈德剂量低于4.0毫克/千克体重时的抑制作用，但对超过4.0毫克剂量的作用影响不大。因子1（10个生物学单位/千克体重）本身也能显著抑制这些淋巴母细胞的生长，且不影响体重或肾上腺重量，其效果相当于单独使用3至4毫克/千克体重剂量的曲安奈德。用0.9%氯化钠溶液处理的大鼠与用因子1处理的大鼠相比，血浆总皮质醇水平或血浆促肾上腺皮质激素水平没有显著差异，并且因子1对培养的L5178Y淋巴母细胞没有细胞毒性作用。因此，因子1可能足以增强小鼠体内生理水平糖皮质激素的作用，以抑制这些淋巴母细胞的生长，而不会对宿主动物造成任何明显的副作用。
