Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 27# Shanda South Road, Jinan 250100, PR China.
Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 27# Shanda South Road, Jinan 250100, PR China.
Environ Int. 2012 Apr;40:244-255. doi: 10.1016/j.envint.2011.12.003. Epub 2012 Jan 14.
A wide application of carbon nanotubes (CNTs) is on the way owing to their unique structural, optical, mechanical and electronic properties, high specific surface area, and facile functionalization. As a result, human beings will inevitably be exposed to CNTs, especially when the tubes are utilized as diagnostic and therapeutic tools to better understand, detect, and treat human diseases. Therefore the new subject of nanotoxicology, which is the study of the toxicity of nanomaterials, is now gaining public concern. This review provides an overview and comments on recent advances (mostly within the last 3 years) in the toxicology of CNTs, including their toxicity targeted to cells, organs, tissues and the whole organism, including mammals and other species (e.g. aquatic species, plants, and bacteria). Not only these traditional subjects of toxicological study but the interaction of CNTs and biomacromolecules is also covered so that the mechanism of their toxicity may be understood and their undesirable properties are more likely to be avoided.
由于碳纳米管 (CNTs) 具有独特的结构、光学、机械和电子特性、高比表面积以及易于功能化等特点，因此它们的应用将会非常广泛。人们将不可避免地接触到 CNTs，特别是当这些管子被用作诊断和治疗工具以更好地了解、检测和治疗人类疾病时。因此，纳米毒理学这一新学科——纳米材料毒性的研究——现在引起了公众的关注。本综述概述并评论了 CNTs 毒理学的最新进展（主要是在过去 3 年内），包括 CNTs 对细胞、器官、组织和整个生物体（包括哺乳动物和其他物种，如水生物种、植物和细菌）的毒性。不仅涵盖了这些传统的毒理学研究课题，还涵盖了 CNTs 与生物大分子的相互作用，以便了解其毒性机制，并更有可能避免其不良特性。
