Chair of Separation Science and Technology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
J Chromatogr A. 2012 Feb 17;1225:141-9. doi: 10.1016/j.chroma.2011.12.072. Epub 2012 Jan 3.
The X-ray computed tomography (CT) is used to determine local parameters related to the column packing homogeneity and hydrodynamics in columns packed with spherically and irregularly shaped particles of same size. The results showed that the variation of porosity and axial dispersion coefficient along the column axis is insignificant, compared to their radial distribution. The methodology of using the data attained by CT measurements to perform a CFD simulation of a batch separation of model binary mixtures, with different concentration and separation factors is demonstrated. The results of the CFD simulation study show that columns packed with spherically shaped particles provide higher yield in comparison to columns packed with irregularly shaped particles only below a certain value of the separation factor. The presented methodology can be used for selecting a suited packing material for a particular separation task.
X 射线计算机断层扫描（CT）用于确定填充相同大小的球形和非球形颗粒的柱中与柱包装均匀性和流体动力学相关的局部参数。结果表明，与径向分布相比，沿柱轴的孔隙率和轴向扩散系数的变化不显著。展示了使用 CT 测量获得的数据执行具有不同浓度和分离因子的模型二元混合物分批分离的 CFD 模拟的方法。CFD 模拟研究的结果表明，与仅在一定分离因子值以下的非球形颗粒填充的柱相比，球形颗粒填充的柱在比较时提供了更高的产率。所提出的方法可用于为特定分离任务选择合适的填充材料。
