Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
Hum Immunol. 2012 Mar;73(3):298-300. doi: 10.1016/j.humimm.2011.12.021. Epub 2011 Dec 28.
IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection.
IL28B 单核苷酸多态性 (SNPs) 与丙型肝炎病毒 (HCV) 的自发性和治疗诱导清除有关。为了评估 IL28B rs8099917 SNP 是否也影响慢性 HCV 感染的进展，我们对 511 名日本 HCV 患者进行了基因分型，包括 69 名肝细胞癌 (HCC) 患者。rs8099917 的 T/T 基因型与 HCC 的发生无关 (p = 0.623)，尽管逐步逻辑回归分析表明肝硬化、年龄大于 68 岁和血清白蛋白 <4.2mg/dl 与 HCC 发病有关。看来，IL28B SNP 不会直接影响慢性 HCV 感染中的肝癌发生。
