背侧丘脑“非特异性”胆碱酯酶组织化学染色的分布：啮齿动物的比较研究

Distribution of 'non-specific' cholinesterase histochemical staining in the dorsal thalamus: a comparative study in rodents.

作者信息

Liu N H, Yu B P, Gallardo K A, Robertson R T

机构信息

Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine 92717.

出版信息

Brain Res. 1990 Jul 9;522(2):315-21. doi: 10.1016/0006-8993(90)91475-v.

DOI:10.1016/0006-8993(90)91475-v

PMID:2224529

Abstract

Histochemical studies in rat dorsal thalamus demonstrate that 'non-specific' cholinesterase (ChE) enzyme activity is characteristic of neurons of the anterior dorsal (AD) and reuniens (Re) nuclei and in a cell group found as part of the central lateral (CL) and lateral dorsal (LD) nuclei. Extra-somatal ChE staining also is seen in the anterior ventral (AV) nucleus. Parallel histochemical studies in other rodents reveal slight ChE activity in neurons of the mouse AD and LD, but not in other thalamic nuclei. The dorsal thalami of hamsters, gerbils and guinea pigs show no detectable cellular staining of ChE, although low levels of extra-somatal ChE appear in AV and the internal medullary lamina. These data indicate that 'non-specific' cholinesterase activity is not found commonly in neurons of the dorsal thalamus and prominent ChE staining may be unique to the laboratory rat.

摘要

对大鼠背侧丘脑的组织化学研究表明，“非特异性”胆碱酯酶（ChE）活性是背侧前核（AD）和中央正中核（Re）神经元以及作为中央外侧核（CL）和背侧外侧核（LD）一部分的细胞群的特征。在腹侧前核（AV）中也可见胞外ChE染色。对其他啮齿动物的平行组织化学研究显示，小鼠AD和LD神经元中有轻微的ChE活性，但其他丘脑核中没有。仓鼠、沙鼠和豚鼠的背侧丘脑未显示出可检测到的ChE细胞染色，尽管在AV和内髓板中出现了低水平的胞外ChE。这些数据表明，“非特异性”胆碱酯酶活性在背侧丘脑神经元中并不常见，显著的ChE染色可能是实验大鼠所特有的。