Division of Emergency Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
Curr Opin Pediatr. 2012 Apr;24(2):225-32. doi: 10.1097/MOP.0b013e3283504f88.
Procedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department.
Numerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized.
We review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.
在急诊科，为了缓解儿童的疼痛和焦虑，操作镇静已成为标准治疗方法。
虽然已经发表了许多关于儿科操作镇静的文章，但很少有深入讨论所用镇静剂的药效学和药代动力学的文章。
我们从临床角度回顾了儿科操作镇静药物的药代动力学和药效学，重点讨论了药物滴定和剂量的实际意义。
