p38γ 活性对于维持慢肌纤维的大小是必需的。
p38γ activity is required for maintenance of slow skeletal muscle size.
机构信息
Molecular, Cellular, and Integrated Physiology Program, University of California at Los Angeles, Los Angeles, California, USA.
出版信息
Muscle Nerve. 2012 Feb;45(2):266-73. doi: 10.1002/mus.22289.
Abstract
INTRODUCTION
p38γ kinase is highly enriched in skeletal muscle and is implicated in myotube formation. However, the activation status of p38γ in muscle is unclear.
METHODS
p38γ activity in slow and fast adult mouse skeletal muscle tissue was examined, as was the impact of p38γ deficiency on muscle development and gene expression.
RESULTS
p38γ is preferentially activated in slow muscle, but it is inactive in fast muscle types. Furthermore, the loss of p38γ in mice led to decreased muscle mass associated with a smaller myofiber diameter in slow muscle, but there was no impact on fast muscle in either mass or myofiber diameter. Finally, p38γ-deficient muscle showed selective changes in genes related to muscle growth in slow muscle fibers.
CONCLUSION
This study provides evidence that p38γ is selectively activated in slow skeletal muscle and is involved in the normal growth and development of a subset of skeletal muscle.
摘要
简介
p38γ 激酶在骨骼肌中高度富集，并与肌管形成有关。然而，肌肉中 p38γ 的激活状态尚不清楚。
方法
研究了慢肌和快肌成年小鼠骨骼肌组织中 p38γ 的活性，以及 p38γ 缺失对肌肉发育和基因表达的影响。
结果
p38γ 在慢肌中优先激活，但在快肌类型中不活跃。此外，p38γ 缺失的小鼠肌肉质量下降，与慢肌中肌纤维直径减小有关，但对快肌的质量或肌纤维直径没有影响。最后，p38γ 缺陷肌肉中与慢肌纤维生长相关的基因出现了选择性变化。
结论
本研究提供的证据表明，p38γ 在慢骨骼肌中被选择性激活，并参与了一部分骨骼肌的正常生长和发育。
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