Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Head Neck. 2013 Jan;35(1):28-34. doi: 10.1002/hed.22909. Epub 2012 Jan 13.
The purpose of this study was to analyze the relationship between cytologic features, clinical features, and recurrence of papillary thyroid cancer (PTC). We hoped to predict prognosis preoperatively.
We retrospectively studied cytologic features by using computerized morphometry and clinical data of 118 patients with usual-type PTC without initial metastasis, including 34 patients with cancer recurrence in 10 years after surgery and 84 patients who did not have recurrence for more than 10 years after surgery. Another 24 patients were recruited for validation.
Multivariate logistic analysis indicated that nucleus-to-cell ratio, variation of nuclear area, tumor size, and patient age were significantly related to recurrence. Cox regression analysis showed that hazard ratios were 3.34, 1.53, 1.77, and 2.6, respectively.
Cytologic features of PTC analyzed with computerized morphometry significantly correlated with recurrence. It helped to predict prognosis preoperatively and may be helpful for planning further treatment.
本研究旨在分析甲状腺乳头状癌（PTC）的细胞学特征、临床特征与复发之间的关系，以便术前预测预后。
我们回顾性地研究了 118 例无初始转移的常见型 PTC 患者的细胞学特征和临床资料，其中 34 例患者在手术后 10 年内复发，84 例患者在手术后 10 年以上无复发，另外招募了 24 例患者进行验证。
多变量逻辑分析表明，核-细胞比、核面积变化、肿瘤大小和患者年龄与复发显著相关。Cox 回归分析显示，危险比分别为 3.34、1.53、1.77 和 2.6。
计算机形态计量学分析的 PTC 细胞学特征与复发显著相关，有助于术前预测预后，并可能有助于制定进一步的治疗计划。
