Department of Pediatrics, Odense University Hospital, Odense, Denmark.
Arch Dis Child. 2012 Mar;97(3):227-32. doi: 10.1136/archdischild-2011-300597. Epub 2012 Jan 13.
To describe prevalence, prenatal diagnosis and epidemiological data on oesophageal atresia from 23 well-defined European regions and compare the prevalence between these regions.
Population-based study using data from a large European database for surveillance of congenital anomalies (EUROCAT) for two decades (1987-2006).
Twenty-three participating registries based on multiple sources of information including information about live births, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy.
1222 cases of oesophageal atresia in a population of 5 019 804 births.
The overall prevalence was 2.43 cases per 10 000 births (95% CI 2.30 to 2.57). There were regional differences in prevalence ranging from 1.27 to 4.55. Prenatal detection rates varied by registry from >50% of cases to <10% of cases. A total of 546 cases (44.7%) had an isolated oesophageal anomaly, 386 (31.6%) were multiple malformed and 290 (23.7%) had an association or a syndrome. There were 1084 live born cases (88.7%), 43 cases were fetal deaths and 95 cases were terminations of pregnancy. One-week survival for live births was 86.9% and 99.2% if the gestational age was ≥38 weeks and isolated oesophageal atresia was present. Males accounted for 57.3% of all cases and 38.5% of live born cases were born with gestational age <37 weeks.
There were regional differences in prevalence of oesophageal atresia in Europe. Half of all cases had associated anomalies. Prenatal detection rate increased from 26% to 36.5% over the two decades. Survival in infants with isolated oesophageal atresia born at term is high.
描述 23 个明确界定的欧洲地区食管闭锁的流行率、产前诊断和流行病学数据，并比较这些地区之间的流行率。
使用欧洲先天性异常监测大型数据库（EUROCAT）二十年（1987-2006 年）的数据进行基于人群的研究。
23 个参与的登记处基于多种信息来源，包括活产、孕龄≥20 周的胎儿死亡和终止妊娠的信息。
1222 例食管闭锁患者，来自 5019804 例出生人口。
总体患病率为每 10000 例出生 2.43 例（95%CI 2.30 至 2.57）。患病率存在地区差异，范围为 1.27 至 4.55。各登记处的产前检出率从>50%的病例到<10%的病例不等。共有 546 例（44.7%）存在单纯食管异常，386 例（31.6%）为多发性畸形，290 例（23.7%）存在关联或综合征。有 1084 例活产（88.7%），43 例胎儿死亡，95 例终止妊娠。活产的 1 周生存率为 86.9%，如果孕龄≥38 周且存在单纯食管闭锁，生存率为 99.2%。所有病例中男性占 57.3%，活产中 38.5%的婴儿出生时孕龄<37 周。
欧洲食管闭锁的流行率存在地区差异。一半的病例存在相关畸形。在这二十年中，产前检出率从 26%增加到 36.5%。在足月出生的单纯食管闭锁婴儿中，存活率较高。
