CD4+T 细胞分化状态与 HIV-1 围生期感染儿童疾病进展的关系。
Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children.
机构信息
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
出版信息
PLoS One. 2012;7(1):e29154. doi: 10.1371/journal.pone.0029154. Epub 2012 Jan 11.
BACKGROUND
In the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The course of HIV-1 infection in these children is variable, and understudied.
METHODOLOGY/PRINCIPAL FINDINGS: We determined whether qualitative differences in immune cell subsets could explain a slower disease course in long term survivors with no evidence of immune suppression (LTS-NS; CD4%≥25%) compared to those with severe immune suppression (LTS-SS; CD4%≤15%). Subjects in the LTS-NS group had significantly higher frequencies of naïve (CCR7+CD45RA+) and central memory (CCR7+CD45RA-) CD4+ T cells compared to LTS-SS subjects (p = 0.0005 and <0.0001, respectively). Subjects in the rapid progressing group had significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells compared to slow progressing subjects (p<0.0001).
CONCLUSIONS/SIGNIFICANCE: Rapid disease progression in vertical infection is associated with significantly higher levels of CD4+ T(EMRA) (CCR7-CD45RA+) cells.
背景
在美国，大多数 HIV-1 感染儿童都接受抗逆转录病毒药物治疗，许多人能够从中度过青少年期并进入成年期。这些儿童中 HIV-1 感染的病程是可变的，且研究不足。
方法/主要发现：我们确定了免疫细胞亚群的定性差异是否可以解释无免疫抑制证据的长期存活者（LTS-NS；CD4%≥25%）与严重免疫抑制者（LTS-SS；CD4%≤15%）相比，疾病进程较慢。与 LTS-SS 受试者相比，LTS-NS 组受试者的幼稚（CCR7+CD45RA+）和中央记忆（CCR7+CD45RA-）CD4+T 细胞频率明显更高（p=0.0005 和 <0.0001）。与进展缓慢的受试者相比，快速进展组的 CD4+T（EMRA）（CCR7-CD45RA+）细胞水平明显更高（p<0.0001）。
结论/意义：垂直感染中的快速疾病进展与 CD4+T（EMRA）（CCR7-CD45RA+）细胞水平显著升高有关。
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