Northfield John W, Loo Christopher P, Barbour Jason D, Spotts Gerald, Hecht Frederick M, Klenerman Paul, Nixon Douglas F, Michaëlsson Jakob
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom.
J Virol. 2007 Jun;81(11):5759-65. doi: 10.1128/JVI.00045-07. Epub 2007 Mar 21.
CD8(+) T cells are believed to play an important role in the control of human immunodeficiency virus type 1 (HIV-1) infection. However, despite intensive efforts, it has not been possible to consistently link the overall magnitude of the CD8(+) T-cell response with control of HIV-1. Here, we have investigated the association of different CD8(+) memory T-cell subsets responding to HIV-1 in early infection with future control of HIV-1 viremia. Our results demonstrate that both a larger proportion and an absolute number of HIV-1-specific CD8(+) CCR7(-) CD45RA(+) effector memory T cells (T(EMRA) cells) were associated with a lower future viral load set point. In contrast, a larger absolute number of HIV-1-specific CD8(+) CCR7(-) CD45RA(-) effector memory T cells (T(EM)) was not related to the viral load set point. Overall, the findings suggest that CD8(+) T(EMRA) cells have superior antiviral activity and indicate that both qualitative and quantitative aspects of the CD8(+) T-cell response need to be considered when defining the characteristics of protective immunity to HIV-1.
人们认为CD8(+) T细胞在控制人类免疫缺陷病毒1型（HIV-1）感染中发挥着重要作用。然而，尽管付出了巨大努力，但始终无法将CD8(+) T细胞反应的总体强度与HIV-1的控制联系起来。在此，我们研究了早期感染时对HIV-1产生反应的不同CD8(+)记忆T细胞亚群与未来HIV-1病毒血症控制之间的关联。我们的结果表明，HIV-1特异性CD8(+) CCR7(-) CD45RA(+)效应记忆T细胞（T(EMRA)细胞）的比例增加和绝对数量增多均与未来较低的病毒载量设定点相关。相比之下，HIV-1特异性CD8(+) CCR7(-) CD45RA(-)效应记忆T细胞（T(EM)）的绝对数量增加与病毒载量设定点无关。总体而言，这些发现表明CD8(+) T(EMRA)细胞具有更强的抗病毒活性，并表明在定义针对HIV-1的保护性免疫特征时，需要同时考虑CD8(+) T细胞反应的质量和数量方面。
